Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
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Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
MicroRNAs (miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post-transcriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expanding the number of mutated miRNA genes to 95, or 83% of known C. elegans miRNAs. We find that the majority of miRNAs are not essential for the viab...
متن کاملMany families of Caenorhabditis elegans microRNAs are not essential for development or viability
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Summary MicroRNAs (miRNAs) are approximately 23 nt regulatory RNAs that posttranscriptionally inhibit the functions of protein-coding mRNAs. We previously found that most C. elegans miRNAs are individually not essential for development or viability and proposed that paralogous ...
متن کاملMany Families of C. elegans MicroRNAs Are Not Essential for Development or Viability
MicroRNAs (miRNAs) are approximately 23 nt regulatory RNAs that posttranscriptionally inhibit the functions of protein-coding mRNAs. We previously found that most C. elegans miRNAs are individually not essential for development or viability and proposed that paralogous miRNAs might often function redundantly. To test this hypothesis, we generated mutant C. elegans strains that each lack multipl...
متن کاملThe microRNAs of Caenorhabditis elegans.
The soil nematode, Caenorhabditis elegans, occupies a central place in the short history of microRNA (miRNA) research. The converse is also true: miRNAs have emerged as key regulatory components in the life cycle of the worm, as well as numerous other organisms. Since the landmark discovery in 1993 of the first miRNA gene, lin-4, several other miRNAs have been characterized in detail in C. eleg...
متن کاملThe microRNAs of Caenorhabditis elegans.
MicroRNAs (miRNAs) are an abundant class of tiny RNAs thought to regulate the expression of protein-coding genes in plants and animals. In the present study, we describe a computational procedure to identify miRNA genes conserved in more than one genome. Applying this program, known as MiRscan, together with molecular identification and validation methods, we have identified most of the miRNA g...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2007
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.0030215